Dr. Jitesh Chawla discuss smoking
cessation clinical trials-failures and successes
The first anti-nicotine vaccine to enter Phase 3 clinical trial,
NicVax, was in it’s the last stage of testing before hitting the market. The
product works by inciting the immune system to produce antibodies that bind to
nicotine in the bloodstream, much as antibodies would attack an invading microorganism.
Once bound, the nicotine cannot cross the blood-brain barrier to enter the
brain. It is the neurotransmitters in the brain that cause chemical reactions
leading to addictive behavior. The vaccine was therefore expected to diminish
the pleasure of smoking and make it easier to quit. Unfortunately, the failure
of the vaccine serves as major set-back to harness the immune system’s power to
fight additions such as tobacco abuse.
Nevertheless, Micro-electric current therapy shows a lot of promise. In one
trial, 1,000 cigarette smokers treated between July 2006 and January 2008, 972
(97.2%) lost their craving for cigarettes within 1 to 5 minutes into a 20
minute session of CES. In those who were in the process of quitting and often
at the height of their withdrawal symptoms, cravings started to diminish within
2 minutes of initiating CES and usually disappeared within 10 minutes. Several
were 2 or 3 weeks into quitting and still experienced craving.
Picture of Micro-electrical current device- as proposed by Dr. Chawla for smoking cessation clincal trials
Picture of Micro-electrical current device- as proposed by Dr. Chawla for smoking cessation clincal trials
There may be many reasons for the difference between success
and failure including the solidity of the product, trial design, lack of
capital, tough FDA reviewers but clinical
trials. Even after successful trials and FDA approval some smoking cessation
products, like the Nicotrol Inhaler,
are not adopted well, as the side-effects and limited efficacy with mediocre
outcomes serves as a stumbling block. It is time to try something new.
Micro-electrical current therapy has a different mechanism of action than any
other therapeutic agent for smoking cessation, currently in the market, and is
worth a shot.
If you interested in gaining access to new treatments to help your long-time smoking habit, when you go look for a doctor who conducst such studies. Dr. Chawla suggests the best way to find out if something works for sure is to conduct a small controlled trial .
If you interested in gaining access to new treatments to help your long-time smoking habit, when you go look for a doctor who conducst such studies. Dr. Chawla suggests the best way to find out if something works for sure is to conduct a small controlled trial .
No comments:
Post a Comment